Mosquitos began biting humans more than a million years ago | An analysis of 38 modern mosquitoes’ DNA suggests an ancestral mosquito species developed a preference for feeding on early humans between 2.9 and 1.6 million years ago,

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Intel's 1986 ICCD paper Performance Optimizations of the 80386 reveals how tightly this was optimized. The entire address translation pipeline -- effective address calculation, segment relocation, and TLB lookup -- completes in 1.5 clock cycles:

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